Chambersburg trailed 28-20 and was in jeopardy of being upset before rattling off three straight wins to close the match.
Colin Runshaw (106) and Tanner Shoap (113) nailed down pins and Garrett Kyner (120) scored a narrow 4-2 decision over Tanner Trephan to close out hte Panthers.
Joseph Porter (132) and Anthony Mancuso had pins in the loss for the Panthers.
Carlisle 35, Harrisburg 24: Brady Meals (132), Ian Shannon (145) and Alic Hasan (195) were the Big 3 for the Thundering Herd, as each recorded a fall for critical bonus points. Rashien Phillips decked Grant Shughart 9-7 at 138, and Christian Gayle needed overtime to defeat Dakota Kuhn 2-1 at 160 for the Cougars.